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Mapping the Natural History of Patients with Hereditary Spastic Paraplegia Type 4

How does hereditary spastic paraplegia type 4 (SPG4) change over time? What are doctors measuring as the disease unfolds? What is the day-to-day experience of patients and families? Although SPG4 is the most common form of hereditary spastic paraplegia—a large group of inherited disorders that affect the long nerve pathways carrying movement signals from the brain down the spinal cord to the legs—these questions have largely gone unanswered.